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Regular check-ups with a healthcare provider can ensure that any signs of kidney stress are detected early
Retatrutide's evidence base runs from Phase 2 results published in the New England Journal of Medicine in 2023 (dose-dependent weight reductions near 24%, HbA1c improvements, documented energy-expenditure increases) to Phase 3 TRIUMPH readouts in 20252026, including TRIUMPH-1's ~28% mean reduction at the 12 mg dose
More than half of those who stopped restarted therapy within a year (42%), and nearly two-thirds did so within two years (58%), Sontha said in a university news release
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